Evidence map›Paper›PMID 42495523›Full record

ArticleiScience2026

ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment.

Lei Wang, Urszula Dougherty, Wenliang He, Lu Gao, Caleb Muefong, Rajesh Sarkar, Jie Du, Ardaman Shergill, Hening Lin, Marc Bissonnette and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lei WangDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Urszula DoughertyDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Wenliang HeDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Lu GaoDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Caleb MuefongDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Rajesh SarkarDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Jie DuDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Ardaman ShergillDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Hening LinDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Marc BissonnetteDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.
Yan Chun LiDepartment of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA.

Funding

Metabolic Regulation of Colonic Senescence and Pathological Implications: Epithelial and Microbial InteractionsR01DK138355 · NIDDK · UNIVERSITY OF CHICAGO · PI Yan Chun LI · 2024 to 2026
$1.7M
NIDDK NIH HHS R01 DK138355
6 · The paper itself

Abstract

Acyl-CoA synthetase short chain family member 2 (ACSS2) catalyzes the conversion of acetate to acetyl-CoA. Here we show that

Indexed as

acetateacetyl-CoAACSS2ACSS2 inhibitorcolorectal cancer

Identifiers

PMID42495523
PMCPMC13392868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.