ArticleFrontiers in neuroscience2026
Altered brain entropy and functional connectivity patterns in peritoneal dialysis patients.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore abnormal changes in brain entropy (BEN) and resting-state functional connectivity (RSFC) in peritoneal dialysis (PD) patients and their associations with cognitive impairment (CI). Methods: Fifty-three PD patients and 49 age-, gender-, and education-matched healthy controls (HCs) were enrolled. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed to calculate BEN and RSFC. Neuropsychological assessments and clinical indicator collection were conducted. PD patients were divided into mild cognitive impairment (MCI) and non-cognitive impairment (NCI) groups using Montreal Cognitive Assessment (MoCA) scores. Correlation analyses were performed between BEN/RSFC values and neuropsychological/clinical indicators. Results: PD patients exhibited significantly poorer performance in multiple cognitive scales than HCs (all Conclusion: Patients with end-stage kidney disease undergoing peritoneal dialysis present abnormal brain entropy and functional connectivity patterns. These alterations are associated with systemic metabolic disorders, long-term dialysis treatment, and cognitive/emotional impairment.
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