ArticleFrontiers in pediatrics2026
Early arterial blood gas parameters, clinical features, and neuroimaging findings in neonates undergoing therapeutic hypothermia for suspected hypoxic-ischemic encephalopathy: a retrospective single-center study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypoxic-ischemic encephalopathy (HIE) remains an important cause of neonatal mortality and long-term neurodevelopmental impairment. Although therapeutic hypothermia is the standard treatment for term and near-term infants with suspected moderate-to-severe HIE, the relationships among early blood gas parameters, clinical findings, and radiologic abnormalities in cooled neonates are not fully defined. Methods: This retrospective observational study included neonates aged 0-28 days who underwent therapeutic hypothermia for suspected HIE at any neonatal intensive care unit and were subsequently evaluated by the Department of Pediatric Neurology at Biruni University Hospital. Demographic and perinatal characteristics, blood gas parameters, seizure status, electroencephalographic findings, antiepileptic treatment, cranial ultrasonography, and cranial MRI findings were obtained from medical records. Final HIE classification was assigned retrospectively after review of the clinical course, documented seizures, serial neurologic findings, electroencephalographic data, and neuroimaging findings. Results: A total of 22 neonates were included. Final HIE classification identified no final evidence of HIE in 16 patients (72.7%), stage 1 HIE in 1 (4.5%), stage 2 HIE in 3 (13.6%), and stage 3 HIE in 2 (9.1%). Compared with neonates without HIE, those with any HIE had significantly lower bicarbonate levels ( Conclusions: Lower bicarbonate levels were associated with the presence of any-stage HIE compared with no final evidence of HIE, while more severe metabolic acidosis was associated with seizure occurrence. The bicarbonate finding was consistent with previously established evidence and should be interpreted as supportive rather than novel. The discordance between cranial ultrasonography and MRI was consistent with the previously established greater sensitivity of MRI and was considered a supportive secondary finding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.