ArticleDose-response : a publication of International Hormesis Society
Hormesis as a Geometric Necessity of Bounded Adaptive Systems: Quantitative Predictions From First Principles.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To determine whether hormesis can be derived from the geometry of bounded adaptive biological endpoints, and whether the derivation yields quantitative predictions independent of curve fitting. Methods: Bounded endpoints were represented in rapidity coordinates using the arctanh linearisation of the adopted Möbius composition law. Repair activation and damage accumulation were modelled as opposing bounded rapidity increments with independently measurable thresholds. The molecular-to-functional attenuation factor was derived for linear pathways from the metabolic-control summation theorem and separated from a testable multi-target extension. Predictions were compared with published H Results: The model predicts a biphasic response whenever repair activation precedes toxicity (D Conclusion: Within the stated scope of independently composing bounded adaptive endpoints, hormesis follows from finite repair capacity plus adaptive upregulation. The framework does not claim that all biological history is axiomatic; it identifies the conditional geometry that constrains dose-response shape once a bounded adaptive endpoint is specified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.