Evidence map›Paper›PMID 42495159›Full record

ArticleInnovation in aging2026

Persistent financial adversity and cognitive aging: a life course investigation.

Yiwen Liu, Jacques Wels, Sarah-Naomi James, Sarah E Keuss, Jane Maddock, Thomas D Parker, Jean Stafford, Jonathan M Schott, Marcus Richards, Praveetha Patalay

Abstract read
In one paragraph

Article in Innovation in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiwen LiuUnit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, United Kingdom.
Jacques WelsUnit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-9292-917X
Sarah-Naomi JamesUnit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-3800-4416
Sarah E KeussDementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom.
Jane MaddockUnit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-7975-4221
Thomas D ParkerDementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom.
Jean StaffordAdvanced Care Research Centre (ACRC), University of Edinburgh, Edinburgh, United Kingdom.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID https://orcid.org/0000-0003-2059-024X
Marcus RichardsUnit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-9191-2192
Praveetha PatalayUnit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-5341-3461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: The long-term effect of persistent financial adversity on cognitive aging remains unclear. We examined how sustained financial hardship across adulthood associates with midlife cognition, cognitive decline, and later-life brain health and whether impacts vary by sex, childhood socioeconomic circumstances (SECs), and genetic risk. Research Design and Methods: Using data from the 1946 British birth cohort ( Results: Increased exposure to low household income and financial hardships was associated with lower processing speed (-0.07 [-0.13, -0.02] and -0.05 [-0.11, -0.00]) and verbal memory at age 53 (-0.16 [-0.21, -0.11] and -0.10 [-0.15, -0.05]). This was followed by slower verbal memory decline, attributable to lower baseline scores. Persistent low income was associated with greater ventricular volume ( Discussion and Implications: Persistent financial adversity impacts cognitive performance by midlife and later-life brain atrophy, with larger effects for men, those from disadvantaged childhoods, and individuals with greater genetic risk. Supporting financially vulnerable working-age adults could help prevent dementia in an aging population.

Indexed as

Brain atrophyCognitionCognitive declineNeuroimaging

Identifiers

PMID42495159
PMCPMC13395473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.