Evidence map›Paper›PMID 42494902›Full record

ArticleFrontiers in public health2026

Fluoroquinolone resistance and mutation profiles in

Yongming Lin, Yong Zhao, Jian Lin, Shufang Lin, Zhisong Dai, Shuzhen Wei

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Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yongming Lin *Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
Yong Zhao *Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
Jian LinFujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
Shufang LinFujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
Zhisong DaiFujian Provincial Center for Disease Control and Prevention, Fuzhou, China.
Shuzhen WeiFujian Provincial Center for Disease Control and Prevention, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to characterize fluoroquinolone (FQs) resistance and associated gene mutations in Methods: A retrospective analysis was performed on 150 clinical MTB isolates collected from drug resistance surveillance sites. Phenotypic drug susceptibility testing (pDST) for FQs was conducted using the proportion method on solid Löwenstein-Jensen (L-J) media. In parallel, whole-genome sequencing (WGS) was applied to identify resistance-associated gene mutations. Results: The overall phenotypic resistance rate to FQs was 12.7%, increasing markedly to 26.7% among multidrug-resistant (MDR) strains. The isolates were mainly classified into lineage L2 (60.0%) and L4 (38.7%), with no statistically significant association observed between lineage distribution and drug resistance profiles. Mutations linked to FQs resistance were predominantly identified in the Conclusion: FQs resistance among MTB isolates in this study is considerable, with a particularly high burden in MDR strains. Resistance is mainly driven by single-point mutations in the

Indexed as

Antitubercular AgentsDrug Resistance, BacterialFluoroquinolonesMutationMycobacterium tuberculosisTuberculosis, Multidrug-ResistantChinaDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsRetrospective StudiesWhole Genome SequencingAntitubercular AgentsFluoroquinolonesdrug resistancefluoroquinolonegene mutationMycobacterium tuberculosiswhole-genome sequencing

Identifiers

PMID42494902
PMCPMC13391534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.