ArticleJournal of extracellular biology2026
Secretion of Extracellular Vesicles Into the Mesenteric Lymph During Fasting and Lipid Absorption.
Article in Journal of extracellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestine plays critical roles in nutrient homeostasis and systemic health. The small intestine is the major organ that packages dietary lipids into chylomicrons and secretes them into the mesenteric lymph. Extracellular vesicles (EVs) as a mechanism for cell-to-cell communication often exhibit organ specific characteristics. EV secretion from the intestine into the mesenteric lymph-a unique biofluid-remains unexplored. To characterize gut-derived EVs, Sprague-Dawley rats were surgically implanted with cannula in the mesenteric lymph duct (for lymph collection) and the duodenum (for lipid infusion). Lymph fluid was collected for assessment of EV secretion. EVs in lymph fluids collected before and after lipid infusion were characterized by transmission electron microscopy, nanoparticle tracking analysis, and further analyzed by flow cytometry with antibodies against CD63, CD81, CD9 and apolipoprotein B (ApoB). Lipid infusion increased lymph triglyceride output peaking at 2 h. Lymph fluids contained EVs with diameters in the range of 20 to 300 nm and the signals of specific EV markers CD63, CD81 and CD9 were significantly elevated following lipid infusion. Depletion of chylomicrons from lymph had differential effects on the percentage and intensity of CD63, CD81 and CD9. In addition, these EVs exhibited distinct patterns in ApoB
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