Evidence map›Paper›PMID 42494724›Full record

ArticleObesity science & practice2026

Prevalence, Comorbidities, and Mortality of Obesity Classes 4 and 5 in Adults.

Katelynn Tran, Xinlian Zhang, Phillipp Hartmann

Abstract read
In one paragraph

Article in Obesity science & practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katelynn TranDepartment of Pediatrics University of California San Diego La Jolla California USA.
Xinlian ZhangDivision of Biostatistics and Bioinformatics Herbert Wertheim School of Public Health and Human Longevity Science University of California San Diego La Jolla California USA.
Phillipp HartmannDepartment of Pediatrics University of California San Diego La Jolla California USA.ORCID https://orcid.org/0000-0003-3658-3335

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
Developing Diverse Physician-Investigator Leaders for the Future of Child HealthK12HD105271 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Gabriel G Haddad · 2021 to 2026
$1.8M
NCATS NIH HHS KL2 TR001444NICHD NIH HHS K12 HD105271NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

Introduction: Adult obesity has reached epidemic proportions globally. Although the prevalence and comorbidities of standard obesity classes (classes 1-3, BMI 30-49.9 kg/m Objective: The objective of this study was to determine the prevalence of obesity classes 4 and 5, or extremely severe obesity, in adults over time and to investigate the relationship between extremely severe obesity and metabolic comorbidities and mortality. Methods: Data from nationally representative samples from National Health and Nutrition Examination Surveys from 2000 through 2023 involving 54,793 adults aged 18-65 years in the US were analyzed, including mortality data from 43,454 adults. Results: The prevalence of obesity classes 4 and 5 increased by over 250% from 0.6% in 2000 to 2.2% in 2023 ( Conclusions: The findings highlight the rise of a so far insufficiently characterized obesity entity, extremely severe obesity, and underline the strong association of extremely severe obesity with severe metabolic complications including death. These results emphasize the need for immediate public health interventions to address obesity, particularly obesity classes 4 and 5.

Indexed as

adulthood obesitycardiovascular risk factorsinsulin resistanceMASLDmetabolic syndrome

Identifiers

PMID42494724
PMCPMC13391446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.