ArticleVeterinary world2026
Insulin-like growth factor 1 supplementation during
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Background and Aim: Materials and Methods: Cumulus-oocyte complexes were collected from Kacang goat ovaries and cultured under IVM conditions either without supplementation (control) or with 100 ng/mL IGF-1. Relative expression of Results: IGF-1 supplementation significantly increased the expression of both Conclusion: Supplementation of IVM medium with 100 ng/mL IGF-1 enhanced the expression of HRas, Cdc25, and IRS-2 in Kacang goat oocytes, suggesting activation of molecular pathways associated with meiotic resumption and metabolic regulation. These findings provide mechanistic insights into IGF-1-mediated signaling during oocyte maturation and may help optimize IVM systems for indigenous goat breeds. This improvement in reproductive biotechnology is also relevant to Sustainable Development Goal 2 (Zero Hunger), particularly in supporting sustainable livestock production, conservation of indigenous goat genetic resources, and food security. Nevertheless, further studies evaluating nuclear maturation, fertilization, and embryo developmental competence are required to confirm the functional significance of these molecular responses.
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