ArticleFrontiers in oncology2026
Lurbinectedin in treating CNS metastases from small cell neuroendocrine prostate cancer-a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Case presentation: A 57-year-old man presenting with tenesmus, dyschezia, and urinary retention was diagnosed with high-grade neuroendocrine prostate carcinoma with low prostate-specific antigen (PSA) and high proliferative index. Genomic profiling revealed alterations in ATM and BRCA2 and was negative for Rb1 and TP53. He achieved complete systemic response following platinum-based chemoradiotherapy and immunotherapy but later developed multifocal brain metastases with suspected leptomeningeal involvement. Intervention and outcomes: After progression on whole-brain radiotherapy and topotecan, lurbinectedin was initiated. Imaging demonstrated marked intracranial response, including resolution and reduction of multiple lesions. Disease progression occurred after six cycles. Discussion: This case underscores similarities between neuroendocrine prostate carcinoma and SCLC, supporting the use of SCLC-based therapies. The observed response suggests that lurbinectedin may have clinically meaningful CNS activity, even after failure of standard CNS-directed treatments. Conclusion: Lurbinectedin may be a therapeutic option in CNS-dominant neuroendocrine prostate carcinomas. Further studies are needed to better define its intracranial efficacy and durability of response.
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