Extracellular matrix remodelling in degenerative cervical myelopathy.

Noah D Poulin, Sydney Brockie, Koby Baranes, James Hong, Cindy Zhou, Sarah Sadat, Mark R Kotter, Michael G Fehlings

Abstract read

In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noah D PoulinDepartment of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Sydney BrockieDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Canada M5T 2S8.

Koby BaranesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

James HongDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Canada M5T 2S8.

Cindy ZhouDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Canada M5T 2S8.

Sarah SadatDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Canada M5T 2S8.

Mark R KotterDepartment of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

Michael G FehlingsDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Canada M5T 2S8.ORCID https://orcid.org/0000-0002-5722-6364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degenerative cervical myelopathy (DCM), a type of spinal cord injury triggered by chronic compression from degenerative changes of the spine, induces pathophysiological changes similar to traumatic spinal cord injury, including reactive gliosis, demyelination and neuron loss. However, the effects of chronic spinal cord compression on extracellular matrix composition and organization remain uncharacterized. Here, we analyse untreated post-mortem human tissue and a mouse model of chronic spinal cord compression using immunohistochemical and transcriptomic approaches to assess chondroitin sulphate proteoglycan (CSPG) and fibrosis-related matrix deposition. In human post-mortem tissue, astrogliosis, CSPG accumulation and fibrotic collagen deposition were elevated in the DCM cases (

Indexed as

astrogliosisblood–spinal cord barrierchronic compressionfibrosismatrisome

Identifiers

PMID42494494

DOI10.1093/braincomms/fcag239

PMCPMC13392463

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.