Evidence map›Paper›PMID 42494464›Full record

ArticleResuscitation plus2026

Conservative versus liberal oxygen therapy in hypoxic ischemic encephalopathy following cardiac arrest: a trial-based cost-effectiveness analysis.

Zhomart Orman, Carol Hodgson, Michael Bailey, Diane Mackle, Anne M Mather, Paul Young, Alisa M Higgins, LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trial Group†

Abstract read
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In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhomart OrmanAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 509 St Kilda Road, Melbourne, Victoria 3004, Australia.
Carol HodgsonAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 509 St Kilda Road, Melbourne, Victoria 3004, Australia.
Michael BaileyAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 509 St Kilda Road, Melbourne, Victoria 3004, Australia.
Diane MackleMedical Research Institute of New Zealand, Level 7, CSB Building, Wellington Hospital, Riddiford St, Newtown, Wellington 6021, New Zealand.
Anne M MatherAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 509 St Kilda Road, Melbourne, Victoria 3004, Australia.
Paul YoungIntensive Care Medicine, Wellington Hospital, Riddiford Street, Newtown, Wellington 6021, New Zealand.
Alisa M HigginsAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 509 St Kilda Road, Melbourne, Victoria 3004, Australia.
LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trial Group†

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The cost-effectiveness of conservative versus liberal oxygen therapy in critically ill adults with post-cardiac arrest hypoxic ischemic encephalopathy is unknown. Methods: A cost-effectiveness analysis alongside the LOGICAL trial was conducted from a health system perspective. Conservative oxygen targeted arterial oxygen saturation (SpO Results: Among 1821 participants (median age 62 years; 28.6% female), 873 were randomized to conservative and 948 to liberal oxygen. Mean per-patient cost was $33,629 ($33,517) in the conservative group, with an incremental cost of -$1392 (95% CI, -$4696 to $1911). Favorable functional outcome occurred in 38.2% with conservative oxygen (risk difference, -1.5 percentage points; 95% CI, -6.1 to 3.2). Incremental QALYs were -0.002 (95% CI, -0.013 to 0.008). Conservative oxygen was associated with cost-savings of $635,151 per QALY forgone with considerable uncertainty (>55% bootstrapped replications). Incremental net monetary benefit was $1173 (95% CI, -$2096 to $4442) at $100,000 per QALY. Conclusions: Conservative oxygen was associated with modest cost savings and small differences in health outcomes, with no clear economic advantage over liberal oxygen.

Indexed as

Cardiac arrestCost-effectivenessEconomic evaluationHypoxic ischemic encephalopathyIntensive careOxygenation therapy

Identifiers

PMID42494464
PMCPMC13393807

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.