SynthesisFrontiers in medicine2026
Comparison of ultrasound-guided quadratus lumborum block and other regional blocks for postoperative pain in cesarean section: a systematic review and meta-analysis of randomized clinical trials.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Acute post-cesarean section (C/S) pain causes adverse maternal outcomes, and multimodal opioid-sparing analgesia is central to Enhanced Recovery after Surgery (ERAS) protocols. Quadratus lumborum block (QLB) is a promising regional technique, but evidence comparing it with other regional blocks remains fragmented. Methods: We conducted a systematic review and meta-analysis of RCTs (PubMed, EMBASE, Web of Science; inception to September 2025). Eligible studies included adults undergoing C/S with QLB. Primary outcome was 24-h cumulative morphine consumption; secondary outcomes included pain scores, recovery metrics, and adverse events. RoB 2 and GRADE assessed study quality and evidence certainty. Results: Twenty-three RCTs (1,935 patients) were included. QLB reduced 24-h (MD = -3.19; 95% CI, -5.09, -1.30; Conclusion: QLB was associated with modest reductions in postoperative opioid consumption and 24-h dynamic pain after C/S; however, the clinical significance is limited (pain reduction below the minimally clinically important difference), and the certainty of evidence is moderate-to-low due to very high heterogeneity (I Systematic review registration: https://doi.org/10.37766/inplasy2026.6.0029, identifier: INPLASY202660029.
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