Evidence map›Paper›PMID 42494423›Full record

ArticleBiochemistry and biophysics reports2026

10,11-Dehydrocurvularin attenuates LPS-induced neuroinflammation in BV2 cells by inhibiting the TLR2/MyD88/NLRP3 signaling pathway.

Chenggang Tian, Jian Sun, Jinting Wang, Yu Wang, Peifeng Wan, Guangqiang Sun, Yanling Mu, Meiyu Geng, Baofu Xu, Yu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenggang TianShandong First Medical University & Shandong Academy of Medical Science, Jinan, Shandong, 250117, China.
Jian SunShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Jinting WangShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Yu WangShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Peifeng WanShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Guangqiang SunShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Yanling MuShandong First Medical University & Shandong Academy of Medical Science, Jinan, Shandong, 250117, China.
Meiyu GengShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Baofu XuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China.
Yu ZhangShandong First Medical University & Shandong Academy of Medical Science, Jinan, Shandong, 250117, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation, driven by microglial activation and Toll-like receptor 2 (TLR2) signaling, is a hallmark of neurodegenerative diseases. While 10,11-Dehydrocurvularin (DCV) is known for its anti-inflammatory properties, its specific effects on neuroinflammation remain poorly understood. This study evaluated DCV in lipopolysaccharide (LPS)-stimulated BV2 microglia. Nitric oxide (NO) was measured via the Griess assay, interleukin-1β (IL-1β) and IL-6 levels were quantified using ELISA or RT-qPCR, and the TLR2/MyD88/NLRP3 pathway was analyzed via Western blotting. To validate the target specificity, we employed a TLR2 agonist (Pam3CSK4), a pharmacological inhibitor (C29), and siRNA-mediated knockdown. Results showed that DCV concentration-dependently inhibited LPS-induced NO production (IC

Indexed as

10,11-DehydrocurvularinBV2NeuroinflammationTLR2

Identifiers

PMID42494423
PMCPMC13393164

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.