ArticleFrontiers in neurology
Integrating Mendelian randomization, machine learning and retrospective clinical data: an exploratory analysis of the cross-disease association between CHB and PD, with a focus on eosinophil alterations.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Epidemiological studies on the association between chronic hepatitis B (CHB) and Parkinson's disease (PD) have yielded inconsistent findings, with causality obscured by confounding and limited mechanistic evidence. Methods: The study employed an integrated approach encompassing two-sample Mendelian randomization(MR), multi-omics analysis, machine learning-driven gene screening, immune infiltration profiling, and multicenter retrospective clinical validation, with retrospective clinical validation conducted in two independent cohorts. Results: MR provided evidence suggesting a genetically predicted inverse association between susceptibility to CHB and the risk of PD (OR = 0.82-0.94, Conclusion: Genetic susceptibility to chronic hepatitis B is inversely associated with Parkinson's disease risk. The shared pathophysiological landscape potentially involves
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