ReviewEssays in biochemistry2026
Distribution of lactone-signaling system for expression of secondary metabolite biosynthetic gene clusters in Streptomyces species.
Review in Essays in biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many Streptomyces species have a signaling-molecule/receptor system for induction of secondary metabolite biosynthetic gene clusters (BGCs). Signaling molecules hitherto discovered and studied contain five-membered heterocycles, and are classified into three groups, including γ-butyrolactones, γ-butenolides, and furans. These molecules except for avenolide-type are biosynthesized by enzymes harboring an AfsA tandem repeat domain. These enzymes (AfsA homologs) catalyze a transfer of β-ketoacyl moiety to the hydroxyl group of dihydroxyacetone phosphate. Alignment of 59 afsA homolog genes showed that 86% (51/59) of them located adjacent to their possible signaling-molecule receptor genes, which reminds us to readily predict their signaling-molecule/receptor system for expression of BGCs. Apparent exception is the case of afsA-arpA system in Streptomyces griseus, whose distance was around 3.91 Mb. Understanding of the signaling-molecule/receptor system may lead to a practical genome mining strategy to awaken silent BGCs through derepression of transcription using the cognate ligands, signaling molecules.
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