Evidence map›Paper›PMID 42494285›Full record

ArticleMycoses2026

Osteoarticular Sporotrichosis in a Brazilian Endemic Setting: Associated Factors and Outcomes.

Vanessa Caroline Randi Magalhães, Alexandre Sampaio Moura, Fábio do Nascimento Sales, Salene Angelini Colombo, Renata Eliane de Ávila, Jorge Miguel Schettino César, Diana Manzi Viegas, Amanda Cristina Silva Tardelli Pizarro, Ana Cláudia Lyon, Silvia Hees Carvalho and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mycoses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vanessa Caroline Randi MagalhãesDepartment of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-0035-6261
Alexandre Sampaio MouraHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.
Fábio do Nascimento SalesDepartment of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-8819-9664
Salene Angelini ColomboDepartment of Preventive Veterinary Medicine, School of Veterinary, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-2378-8649
Renata Eliane de ÁvilaHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.
Jorge Miguel Schettino CésarHospital Júlia Kubitschek, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-7636-6859
Diana Manzi ViegasHospital Júlia Kubitschek, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.ORCID https://orcid.org/0009-0000-6851-7311
Amanda Cristina Silva Tardelli PizarroHospital João XXIII, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.
Ana Cláudia LyonHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.
Silvia Hees CarvalhoHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-9329-0411
Maria Rita Teixeira DutraHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.
Virginia Antunes AndradeHospital Eduardo de Menezes, Fundação Hospitalar do Estado de Minas Gerais (FHEMIG), Belo Horizonte, Brazil.
Maria Isabel AzevedoDepartment of Preventive Veterinary Medicine, School of Veterinary, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-6886-0221
Nalu Teixeira Aguiar PeresDepartment of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-2762-3200
Daniel Assis SantosDepartment of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-1108-5666

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303762/2020-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 402200/2021-7Conselho Nacional de Desenvolvimento Científico e Tecnológico 408540/2022-2Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-05368-26Fundação de Amparo à Pesquisa do Estado de Minas Gerais BPG-00113-23Ministério da Saúde 440010/2018-7
6 · The paper itself

Abstract

backgroundOsteoarticular infection is an emerging complication of sporotrichosis, often leading to a significant increase in morbidity and longer treatment.

methodsWe conducted a retrospective cohort study of osteoarticular sporotrichosis (OS) in southeastern Brazil (2014-2024) using clinical, epidemiological, and molecular data.

resultsAmong 252 patients, 20 (7.9%) had OS, including 10 (4%) with osteomyelitis. The median age of patients with OS was 58 years (IQR 39-64; range 18-83) and 55% were male. Hypertension (45%), diabetes (40%), alcohol use (40%), smoking (40%), and HIV infection (15%) were the most frequent conditions identified. Cutaneous lesions occurred in 95% of cases, and 90% of patients presented with arthralgia and edema. Multifocal OS was observed in 50% of cases, most commonly affecting the knees, fingers, and wrists. The mean time to diagnosis was 14.2 months. Most patients were treated with itraconazole combined with amphotericin B; 13 required surgical intervention, including 2 amputations. The mean treatment duration was 21 months. Multisystem involvement due to sporotrichosis was observed in 45% of cases, including pulmonary involvement. Mortality was 15%. Diabetes (OR = 4.11; 95% CI, 1.50-11.38; p = 0.006) was independently associated with OS.

conclusionsOS is associated with substantial morbidity and prolonged treatment. Diabetes may increase the risk of OS, while delayed diagnosis jeopardizes outcomes, underscoring the need for early management.

Indexed as

Endemic DiseasesOsteomyelitisSporotrichosisAdolescentAdultAgedAged, 80 and overAmphotericin BAntifungal AgentsBrazilFemaleHumansItraconazoleMaleMiddle AgedRetrospective StudiesAmphotericin BAntifungal AgentsItraconazoleBrazilian cohortdiabetesrisk factorsSporothrix brasiliensissporotrichosis osteoarticular

Identifiers

PMID42494285
PMCPMC13397049

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.