ArticleYonsei medical journal2026
Pharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease.
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
purposeThiopurines remain an effective treatment for maintaining remission in inflammatory bowel disease (IBD), yet their use is often limited by thiopurine-induced leukopenia (TIL), a potentially life-threatening adverse effect. We aimed to investigate pharmacogenetic associations with TIL in patients with IBD. MATERIALS AND
methodsWe retrospectively analyzed 218 thiopurine-treated patients from two independent IBD cohorts with whole-exome sequencing. Pharmacogenetic subgroups were defined using Clinical Pharmacogenetics Implementation Consortium star allele-based molecular phenotypes or genotype-based classifications. Genetic associations with TIL, defined as white blood cell count ≤3000/µL, were analyzed using Andersen-Gill models adjusted for clinical covariates.
results
conclusionOur findings confirm the central role of
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Registered trials
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