ArticleYonsei medical journal2026
High Burden of Invasive Fungal Infection in Korean Pediatric Liver Transplant Recipients: A Single-Center Retrospective Cohort Study (2012-2023).
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe incidence of invasive fungal infection (IFI) in pediatric liver transplant (LT) recipients in Korea has not been characterized; consequently, antifungal prophylaxis is not covered by the national health insurance. We aimed to determine the incidence and epidemiology of IFI. MATERIALS AND
methodsWe conducted a single-center, retrospective study of children (age ≤19 years) who underwent LT at Severance Children's Hospital, Republic of Korea (2012-2023). IFI was defined as fungal isolation from a sterile site (fluid/blood/tissue) with compatible clinical features.
resultsOf the 126 LT cases involving 115 children, 69.0% (n=87) were performed due to biliary atresia. Twenty-four IFI episodes in 20 recipients yielded a 90-day post-LT crude incidence of 19.0% and an incidence rate of 0.14 per 1000 patient-days. Invasive candidiasis predominated (95.4%) with
conclusionIFIs impose a burden on pediatric LT recipients in Korea and are associated with poorer survival. These data support the consideration of universal antifungal prophylaxis. However, multicenter studies are warranted to validate these findings and define the prophylaxis regimen.
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