Evidence map›Paper›PMID 42494179›Full record

ArticleBrain and behavior2026

Passive Oscillatory Body Motion Attenuates Pain-Related Behaviors and Increases β-Endorphin Immunoreactivity in a Murine Fracture Model: A Preliminary Study.

Ryoma Kato, Kazuhiro Hayashi, Yuri Okada, Rina Okura, Fuyu Niida, Jun Miyata, Naoyoshi Sakitani, Yasuhiro Sawada, Akira Ito

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In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ryoma KatoDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kazuhiro HayashiDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yuri OkadaDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Rina OkuraDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Fuyu NiidaDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Jun MiyataDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Naoyoshi SakitaniIntegrated Research Center For Self-Care Technology, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Japan.
Yasuhiro SawadaDepartment of Clinical Research, National Rehabilitation Center For Persons with Disabilities, Tokorozawa, Japan.
Akira ItoDepartment of Advanced Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Funding

JSPS KAKENHI JP24K02797JSPS KAKENHI JP24K22248JSPS KAKENHI JP25K02963Takeda Science Foundation
6 · The paper itself

Abstract

objectiveThis preliminary study aimed to investigate whether passive oscillatory body motion (PBM), a mechanical stimulus that reproduces vertical accelerations comparable to those generated during treadmill running, could activate the β-endorphin (β-END)-related hypothalamus-periaqueductal gray (PAG) pathway and alleviate fracture-induced pain.

methodsA murine fracture model was established in C57BL/6J mice by inducing a left tibial fracture followed by 3 weeks of immobilization. Mice were randomly divided into a PBM group and a control group, and PBM was initiated the day after fracture (±5 mm amplitude, 2 Hz, 30 min/day, 5 days/week, for 3 weeks). To measure pain thresholds, paw withdrawal thresholds were measured in an unblinded manner using the von Frey filament test. β-END immunoreactivity and opioid receptor mu 1 (Oprm1) mRNA in the PAG, as well as pro-opiomelanocortin (Pomc) mRNA expression in the hypothalamus, were analyzed by immunofluorescence and qPCR, respectively.

resultsPBM significantly increased the paw withdrawal threshold ratio (p < 0.001) and β-END immunoreactivity (p = 0.02) in the PAG. Moreover, as an exploratory observation, Pomc mRNA expression tended to increase in the PBM group (p = 0.07), whereas Oprm1 mRNA expression did not differ between the two groups (p = 0.69).

conclusionThis preliminary study provides initial evidence that PBM may attenuate fracture-induced pain-related behaviors and increase β-END immunoreactivity in the PAG, possibly via the hypothalamus-PAG pathway. PBM may represent a potential exercise-mimetic approach for pain relief, although further studies are needed to confirm its efficacy and underlying mechanisms.

Indexed as

beta-EndorphinPainPain ManagementTibial FracturesAnimalsDisease Models, AnimalHypothalamusMaleMiceMice, Inbred C57BLPain ThresholdPeriaqueductal GrayPro-OpiomelanocortinReceptors, Opioid, mubeta-EndorphinPro-OpiomelanocortinReceptors, Opioid, muexercise‐mimetic body motionhypothalamus–PAG pathwaymurine fracture modelperiaqueductal grayβ‐endorphin

Identifiers

PMID42494179
PMCPMC13396874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.