ArticleThe American journal of case reports2026
Adult-Onset Central Nervous System Embryonal Tumor With Neuronal Differentiation: A Diagnostic Challenge.
Article in The American journal of case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Neuroblastoma is the most prevalent extracranial solid tumor in children. Primary central nervous system (CNS) neuroblastoma represents an exceedingly rare histological subtype. Adult-onset CNS embryonal tumors, including neuroblastoma, are particularly uncommon and remain poorly characterized in the medical literature. We present a case of suspected primary CNS neuroblastoma in an adult patient to highlight the diagnostic challenges and aggressive nature associated with this rare condition, particularly in resource-limited settings. CASE REPORT A 32-year-old woman presented with severe, progressively worsening headaches over several weeks that were unresponsive to over-the-counter analgesics. Due to symptom progression, she underwent urgent diagnostic evaluation. Initial non-contrast computed tomography of the brain identified a hyperdense lesion in the right temporal region suggesting acute intratumoral hemorrhage, accompanied by mass effect. Magnetic resonance imaging revealed a complex, heterogeneous, contrast-enhancing mass with internal hemorrhagic components and extensive surrounding vasogenic edema. Accordingly, the patient underwent neurosurgical resection. Histological examination of the resected specimen indicated an embryonal tumor, not otherwise specified, with neuronal differentiation. In the absence of advanced molecular profiling due to institutional resource limitations, primary CNS neuroblastoma remained a strongly suspected diagnosis rather than a definitive conclusion. CONCLUSIONS Primary CNS neuroblastoma in adults is an uncommon clinical entity that presents considerable diagnostic challenges and frequently mimics high-grade gliomas or metastatic lesions on radiographic imaging. This case underscores the aggressive nature of the tumor, the importance of including rare embryonal malignancies in the differential diagnosis, and the diagnostic challenges encountered when molecular confirmation is unavailable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.