ArticlePsychiatry investigation2026
Caregiver Neuroticism Amplifies the Effect of Cognitive Impairment Severity on Caregiver Burden Among Dementia Caregivers.
Article in Psychiatry investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveCaregiver burden shows substantial variability across caregiving contexts. This study examined whether caregiver personality traits, particularly neuroticism, moderate the associations between care-recipient factors such as cognitive impairment severity and neuropsychiatric symptoms, and caregiving-related outcomes including overall burden and symptom-related distress.
methodsCross-sectional data from 214 care-recipient and caregiver dyads attending a geriatric psychiatry clinic were analyzed. Cognitive impairment severity was assessed using the Clinical Dementia Rating (CDR), and neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory (NPI). Caregiving-related outcomes were evaluated using the Zarit Burden Interview (ZBI) and the NPI distress (NPI-D). Caregiver personality traits were assessed with the Big Five Inventory-Korean version. Linear regression models tested associations between care-recipient factors and caregiving-related outcomes, and multiple linear regression models examined moderation by caregiver personality using interaction terms, adjusting for caregiver age, sex, and cohabitation status.
resultsCaregiver neuroticism significantly moderated the associations between cognitive impairment severity and both overall caregiving burden and symptom-related distress by amplifying these associations (CDR×neuroticism interactions: ZBI, B [standard error, SE]=7.948 [3.387], p=0.020; NPI-D, B [SE]=4.498 [1.383], p=0.001).
conclusionCaregiver neuroticism appears to be a key modifier of how cognitive impairment severity translates into overall caregiving burden and symptom-related distress. Incorporating caregiver personality assessment may improve risk stratification and inform more personalized support approaches for caregivers of individuals with cognitive impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.