Evidence map›Paper›PMID 42493706›Full record

ArticleMedScience2026

Norepinephrine-mediated regulation of endogenous Aβ

Isaiah Hoffman, Jennifer A Ross, Marissa Tumasz, Steven A Thomas, Elisabeth J Van Bockstaele

Abstract read
PubMed Publisher
In one paragraph

Article in MedScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isaiah HoffmanDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA, 19102, USA. isaiahhoffman@cdrewu.edu.
Jennifer A RossDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA, 19102, USA.
Marissa TumaszPhiladelphia College of Osteopathic Medicine, Philadelphia, PA, 19131, USA.
Steven A ThomasDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Elisabeth J Van BockstaeleDepartment of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA, 19102, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The locus coeruleus (LC), a cluster of noradrenergic neurons in the dorsal pons, is the brain's main source of norepinephrine (NE), crucial for memory, cognition, and stress response. NE dysregulation has been linked to mood disorders, chronic stress, and neurodegenerative diseases such as Alzheimer's disease (AD). Amyloid-β

Indexed as

amyloiddopamine-β-hydroxylaselocus coeruleusnorepinephrinestress

Identifiers

PMID42493706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.