Evidence map›Paper›PMID 42493705›Full record

ArticleInternational urology and nephrology2026

Temporal trends and sociodemographic determinants of time to nephrectomy in localized renal cell cancer.

Maximilian Filzmayer, Michele Petix, Leonardo Quarta, Filippo Orlandi, Jordan A Goyal, Luca Carmignani, Alberto Briganti, Salvatore Micali, Shahrokh F Shariat, Mike Wenzel and 5 more

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Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maximilian FilzmayerCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada. filzmayer@med.uni-frankfurt.de.ORCID https://orcid.org/0009-0005-5715-9965
Michele PetixCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.
Leonardo QuartaCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.
Filippo OrlandiCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.
Jordan A GoyalCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.
Luca CarmignaniUniversità degli Studi di Milano, Milan, Italy.
Alberto BrigantiVita-Salute San Raffaele University, Milan, Italy.
Salvatore MicaliDepartment of Urology, AOU di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Shahrokh F ShariatDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Mike WenzelDepartment of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.
Miriam I TraumannDepartment of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.
Clara HumkeDepartment of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.
Fred SaadCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.
Felix K-H ChunDepartment of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.
Pierre I KarakiewiczCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProlonged time to nephrectomy (TTN) has been associated with adverse oncologic outcomes. We evaluated temporal trends and sociodemographic determinants of prolonged TTN in surgically treated patients with localized renal cell carcinoma (RCC).

methodsPatients with T1-2 N0 M0 RCC treated with partial (PN) or radical nephrectomy (RN) were identified within the Surveillance, Epidemiology and End Results (SEER) database (2004-2022) and stratified according to TTN ≤ 3 vs. > 3 months. Multivariable logistic regression models identified independent and combined sociodemographic determinants of TTN > 3 months.

resultsAmong 54,365 patients, TTN > 3 months was recorded in 28% of PN and 18% of RN patients. The proportion of TTN > 3 months increased over time in both PN (from 19 to 36%, p < 0.001) and RN (from 11 to 31%, p < 0.001). Higher rates of TTN > 3 months were recorded in non-Caucasian vs. Caucasian patients (PN: 33% vs 25%, OR 1.49; RN: 24% vs 15%, OR 1.74), unmarried vs. married individuals (PN: 33% vs. 25%, OR 1.43; RN: 22% vs. 15%, OR 1.58), and males vs. females (PN: 28% vs 27%, OR 1.18; RN: 18% vs 18%, OR 1.20; all p < 0.001). Combined assessment revealed highest rates in non-Caucasian unmarried males at PN (40%, OR 2.70, p < 0.001) and RN (28%, OR 3.09, p < 0.001) compared to lowest rates in Caucasian married females (PN: 21%; RN: 12%).

conclusionsTTN > 3 months proportion increased over time in localized RCC. In PN and RN, non-Caucasian unmarried males are at highest risk of TTN > 3 months. Therefore, specific focus on these highest risk individuals may be warranted within strategies aimed at minimizing TTN.

Indexed as

DeterminantsKidney cancerNephrectomyTime to surgical treatmentTrends

Identifiers

PMID42493705

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