Evidence map›Paper›PMID 42493679›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026

Construct validity and responsiveness of EQ-5D-3L and EQ VAS in psoriatic arthritis: an evaluation based on the Swedish Rheumatology Quality Register.

Kinza Degerlund-Maldi, Malin Regardt, Camilla Nystrand Länsman, Lena Larsson, Ioannis Parodis, Emelie Heintz

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kinza Degerlund-MaldiDepartment of Learning, Informatics, Management and Ethics (LIME), Health Economic and Policy Research Group, Karolinska Institutet, 171 77, Stockholm, Sweden. kinza.degerlund.maldi.2@ki.se.
Malin RegardtMedical Unit Allied Health Professionals, Karolinska University Hospital, 171 76, Stockholm, Sweden.
Camilla Nystrand LänsmanDepartment of Learning, Informatics, Management and Ethics (LIME), Health Economic and Policy Research Group, Karolinska Institutet, 171 77, Stockholm, Sweden.
Lena LarssonInstitute of Odontology, Sahlgrenska Academy, University of Gothenburg, Box 450, 405 30, Gothenburg, Sweden.
Ioannis ParodisDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Center for Molecular Medicine (CMM), 171 76, Stockholm, Sweden.
Emelie HeintzDepartment of Learning, Informatics, Management and Ethics (LIME), Health Economic and Policy Research Group, Karolinska Institutet, 171 77, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate construct validity and responsiveness of the health-related quality of life (HRQoL) instrument EQ-5D-3L (index, dimensions) and EQ VAS among patients with psoriatic arthritis (PsA).

methodsThis retrospective, register-based study utilised data from the Swedish Rheumatology Quality Register. Known-groups validity was assessed by comparing EQ-5D-3L and EQ VAS results across groups with varying levels of physical function or disease activity. Convergent validity was assessed through correlations with comparator instruments. Responsiveness was assessed by analysing correlations between changes in EQ-5D-3L, EQ VAS, and comparator instruments, as well as by assessing the ability to discriminate between patients who improved and those who did not, using the area under the receiver operating characteristic curve (AUC). To confirm construct validity or responsiveness, ≥ 75% of hypotheses had to be supported.

resultsThe study included 13,105 patients with PsA. EQ-5D-3L and EQ VAS demonstrated moderate to strong correlations with comparator instruments and found expected differences between groups with varying physical function or disease activity. Over 75% of the hypotheses related to construct validity were supported. Regarding responsiveness, several hypotheses for the EQ-5D-3L were not supported, and none of the AUC-related hypotheses for EQ VAS were supported. Overall, less than 75% of the hypotheses related to responsiveness for EQ-5D-3L and EQ VAS were supported.

conclusionThe results from this observational study support construct validity of EQ-5D-3L and EQ VAS among patients with PsA. However, responsiveness was not supported for the EQ-5D-3L dimensions which suggests that the EQ-5D-3L may not fully capture changes in HRQoL from interventions impacting other dimensions than pain/discomfort.

Indexed as

Arthritis, PsoriaticQuality of LifeAdultAgedFemaleHumansMaleMiddle AgedPsychometricsRegistriesReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesSwedenEQ-5DHealth economicsPatient-reported outcome measuresPsychometric propertiesQuality of lifeRheumatology

Identifiers

PMID42493679
PMCPMC13395909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.