Evidence map›Paper›PMID 42493555›Full record

ArticlePediatric research2026

Early neurodevelopment predicts driving experience in early adulthood in a congenital heart disease cohort.

Keith S Baxelbaum, Nancy Burnham, Lyla Hampton, Joshua Fischer, Tyler Kuni, Madisen Harvey, Nasser Douge, J William Gaynor, Elizabeth A Walshe

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Keith S BaxelbaumDepartment of Biomedical and Health Informatics, Data Science and Biostatistics Unit, Children's Hospital of Philadelphia, Philadelphia, PA, USA. baxelbaumk@chop.edu.
Nancy BurnhamDivision of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lyla HamptonDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Joshua FischerDepartment of Biomedical and Health Informatics, Data Science and Biostatistics Unit, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tyler KuniDivision of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Madisen HarveyDivision of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nasser DougeDivision of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J William GaynorDivision of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7955-5604
Elizabeth A WalsheCenter for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0466-4272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurvivors of CHD are at elevated risk for neurodevelopmental impairments and functional implications at the transition to adulthood. This study examined whether early neurodevelopmental indicators predict attainment of a driver's license in early adulthood-a real-world milestone for independence-among CHD survivors.

methodsThis prospective longitudinal cohort study followed children who had surgical treatment for CHD into adulthood. Standardized neurodevelopmental assessments were conducted at age 4 years, including measures of executive function, attention, processing speed and visuomotor function. Participants were followed into young adulthood (ages 18-21), at which time they self-reported whether they had obtained a driver's license or learner's permit. Multivariable logistic regression models were used to examine associations between early cognitive measures and licensure outcome, adjusting for demographic and clinical covariates.

resultsAnalysis included 119 participants who completed both the age-four assessment and follow-up survey in young adulthood. In adjusted models, better inhibition and visuo-motor skills at age four were significantly associated with higher likelihood of driving later: inhibition odds ratio [OR] = 1.38, 95% CI, 1.12-1.78, p < 0.01; visuo-motor OR = 1.06, 95% CI, 1.01-1.11, p < 0.05.

conclusionHigh-level executive and motor control capacities in early childhood were a meaningful predictor of driving in young adulthood among CHD survivors. IMPACT: High level cognitive and motor control-specifically inhibition and visuo-motor skills-at age four were significantly associated with higher likelihood of driving measured at the transition to adulthood. Early identification of children at elevated risk for neurodevelopmental impairment-particularly those with visuo-motor or inhibition challenges-may allow for timely and targeted support towards improving later life functional outcomes.

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.