Evidence map›Paper›PMID 42493550›Full record

ArticleNature neuroscience2026

Replay of procedural memory is independent of the hippocampus.

Emmett J Thompson, Lars B Rollik, Benjamin Waked, Georgina Mills, Sthitapranjya Pati, Jasvin Kaur, Ben Geva, Haoyu Li, Rodrigo Carrasco-Davis, Tom George and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emmett J Thompson *Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.ORCID http://orcid.org/0000-0001-5374-4407
Lars B Rollik *Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.ORCID http://orcid.org/0000-0003-0160-6971
Benjamin WakedSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Georgina MillsSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Sthitapranjya PatiSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Jasvin KaurSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Ben GevaSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Haoyu LiSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Rodrigo Carrasco-DavisGatsby Computational Neuroscience Unit, University College London, London, UK.
Tom GeorgeSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Clementine DomineGatsby Computational Neuroscience Unit, University College London, London, UK.
William DorrellGatsby Computational Neuroscience Unit, University College London, London, UK.
Marcus Stephenson-JonesSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK. m.stephenson-jones@ucl.ac.uk.ORCID http://orcid.org/0000-0003-4718-4452

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 557533Wellcome TrustWellcome Trust (Wellcome) 219627/Z/19/Z
6 · The paper itself

Abstract

Sleep is crucial for consolidating all forms of memory and a core mechanism underlying this process is offline replay. Current models propose that replay originates in the hippocampus and triggers reactivation across cortical and subcortical networks. However, conflicting evidence about the role of the hippocampus in offline consolidation of nondeclarative memories raises the question of whether hippocampal replay drives their consolidation. Here we show that replay occurs in the dorsal striatum during offline consolidation of a procedural memory in mice, independently of the hippocampus, and that its content predicts subsequent performance improvements. Neural sequences linked to salient behavioral events were prioritized for replay, with positive and negative behavioral outcomes having opposing effects on individual replay events. All features of replay persisted despite complete bilateral hippocampal lesions. These findings demonstrate that procedural replay occurs independently of the hippocampus, indicating that replay-driven memory consolidation can operate through parallel, independent mechanisms.

Indexed as

HippocampusMemoryMemory ConsolidationSleepAnimalsMaleMiceMice, Inbred C57BL

Identifiers

PMID42493550
PMCPMC13533836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.