ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026
[Development of a 36-gene signature for predicting recurrence in non-muscle-invasive bladder cancer and validation in a Chinese cohort].
Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo develop a transcriptomic-based recurrence prediction model for non-muscle-invasive bladder cancer (NMIBC), to comprehensively validate its efficacy in an independent Chinese cohort, and to explore the underlying biological mechanisms driving tumor recurrence.
methodsTranscriptome profiling data from the multicenter European Urothelial Cancer Molecular Classification Consortium (UROMOL) cohort (
resultsA 36-gene prognostic signature was identified from 12 170 genes to construct the risk score model. In the training cohort, the model achieved a concordance index (C-index) of 0.702 (95%
conclusionThe 36-gene signature developed in this study demonstrates favorable predictive performance and stability across both the training and independent Chinese cohorts. While exhibiting comparable predictive efficacy to the traditional EORTC scoring system, the model serves as an independent prognostic factor that provides crucial supplementary molecular stratification. Furthermore, the model underscores the critical roles of energy metabolism and ECM remodeling in NMIBC recurrence, providing a valuable molecular basis for precise individualized management of NMIBC patients in China.
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42493447PMC13402069What OpenQuestion holds
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