ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026
[Comparison of clinical outcomes between radical prostatectomy and permanent prostate brachytherapy in patients with oligometastatic prostate cancer: A propensity score-matched study].
Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare radical prostatectomy (RP) versus permanent prostate brachytherapy (PPB) as primary local treatment modalities in delaying disease progression to castration-resistant prostate cancer (CRPC) among patients with oligometastatic prostate cancer (omPCa) receiving standard androgen deprivation therapy (ADT), and to provide clinical evidence for individualized treatment strategies.
methodsWe performed a retrospective cohort analysis of 88 patients diagnosed with omPCa (defined as ≤5 metastatic lesions) at a single tertiary center between April 2011 and August 2019. All the patients, after receiving either RP (
resultsPrior to PSM, the RP and PPB groups exhibited significant differences in key prognostic factors: the PPB group was older (mean 73.2
conclusionFor patients with omPCa receiving ADT, the choice of local therapeutic intervention significantly impacts the time to CRPC. Radical prostatectomy is associated with a markedly longer delay in disease progression to the castration-resistant state compared with permanent prostate brachytherapy, with the treatment modality itself serving as a strong independent prognostic factor. These findings underscore the importance of considering the type of local therapy in the multimodal management of omPCa and provide a rationale for individualized treatment planning. Prospective, randomized trials are necessary to validate these observations and further define optimal therapeutic paradigms.
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Identifiers
42493446PMC13402050What OpenQuestion holds
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