ArticleLife science alliance2026
RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation.
Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Measurement of mRNA translation level has heavily relied on quantifying the amount of polysome-associated RNAs, which would not always reflect efficient translation. To address this, we developed ReleAsing Factor Tethered Editing of RNA (RAFTER), which combined the RNA editing enzyme with translation releasing factor to selectively label successfully translated RNAs. The translation level estimated based on RAFTER correlated well with that by Ribo-seq and Polysome-seq, but with a greatly simplified workflow, which enables it for single-cell analysis.
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