ArticleDrug metabolism and disposition: the biological fate of chemicals2026
Generation and characterization of a serum albumin-humanized mouse model and its utility for detection of albumin adduct formation in vivo.
Article in Drug metabolism and disposition: the biological fate of chemicals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An albumin-humanized mouse model was generated via crossbreeding between albumin-transgenic and albumin-null mice and characterized. Immunoblot analyses confirmed that only human, but not mouse, albumin was expressed, and they revealed that the level of serum human albumin in the albumin-humanized mouse was 5-6 times the level in the albumin-transgenic mouse. Serum albumin levels (measured in plasma) were 3-4 times lower, whereas globulin levels were 2 times higher, in the albumin-humanized than in wild-type mice. The transgene integration site was localized via optical genome mapping to mouse chromosome 14, between 2 marker positions that are 143-kilobase pairs apart. A neighboring gene (alpha fetal protein) to albumin on the human chromosome was confirmed absent in the transgenic mouse. A transgene-mouse genome junction sequence was further identified, enabling a new protocol to distinguish between hemizygous and homozygous albumin-transgenic mice. Transgenic human albumin formed covalent adducts with naphthalene 1,2-oxide (NAO) ex vivo at the Cys
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