Evidence map›Paper›PMID 42492369›Full record

ArticleESMO open2026

Somatic BRCA alterations in breast cancer are associated with distinct biological and clinical patterns according to germline BRCA status.

M Oshi, K Kawashima, M Sugimori, A Yamada, Z Shah, K Onel, I Endo, K Takabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESMO open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M OshiDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, USA; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address: oshi.mas.wc@yokohama-cu.ac.jp.
K KawashimaDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, USA; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
M SugimoriDivision of Cancer Genome Medicine, Yokohama City University Medical Center, Yokohama, Japan.
A YamadaDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Z ShahDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, USA.
K OnelDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, USA; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, USA.
I EndoDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
K TakabeDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, USA; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, USA; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, USA; Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, USA; Department of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Breast Surgery, Fukushima Medical University, Fukushima, Japan.

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor ImmunityR01CA250412 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI ABRAMS, SCOTT I., EVANS, SHARON S · 2021 to 2025
$3.4M
Functional Significance of individual p53 mutations in determining the role of estrogen receptor beta in triple negative breast cancerR01CA251545 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DAS, GOKUL M. · 2021 to 2025
$2.9M
Leveraging the GTP Biosynthetic Pathway for Anti-Tumor TherapiesR37CA248018 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Anna Bianchi-Smiraglia · 2021 to 2026
$2.3M
Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal viewR01EB029596 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI XIA, JUN · 2020 to 2023
$1.4M
NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA250412NCI NIH HHS R01 CA251545NCI NIH HHS R37 CA248018NIBIB NIH HHS R01 EB029596
6 · The paper itself

Abstract

backgroundComprehensive genomic profiling increasingly identifies BRCA alterations in breast cancer (BC). While germline BRCA mutations are well established as biologically and clinically relevant, the significance of somatic BRCA alterations remains unclear. We hypothesized that the implications of BRCA alterations may differ according to germline BRCA alterations. PATIENTS AND

methodsAmong 5411 BC cases registered in the Center for Cancer Genomics and Advanced Therapeutics database, we analyzed 2978 BC cases with available germline (g) and somatic (s) BRCA status. Patients were categorized into four groups (g

resultsg

conclusionsBRCA alteration groups defined by combined germline and somatic status showed distinct genomic and clinical patterns in BC. Somatic BRCA alterations should not be interpreted in isolation and require integration with germline status and broader genomic context.

Indexed as

BRCA1 ProteinBRCA2 ProteinBreast NeoplasmsGerm-Line MutationAdultAgedFemaleHumansMiddle AgedBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanbreast cancercdk4/6 inhibitorscomprehensive genomic profilinggermline BRCAsomatic BRCAtumor evolution

Identifiers

PMID42492369
PMCPMC13425830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.