Evidence map›Paper›PMID 42492361›Full record

ArticleRedox biology2026

Aglycemia triggers alternative electron transport to sustain mesenchymal stem cell survival under anoxia.

Alice Refeyton, Nivea Dias Amoedo, Veronique Labat, Thibaut Vignane, Corinne Buré, Benoit Pinson, Seyta Ley-Ngardigal, Christelle Debeissat, Biljana Bursac, Stéphane Claverol and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alice RefeytonEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France; Children's Hospital of Philadelphia, Philadelphia, USA.
Nivea Dias AmoedoEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Veronique LabatEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Thibaut VignaneLeibniz Institute for Analytical Sciences, ISAS e.V., Dortmund, Germany; Institute of Molecular Systems Medicine, Goethe University of Frankfurt, Faculty of Medicine, Frankfurt, Germany.
Corinne BuréService Analyses Métaboliques-TBMCore University of Bordeaux, UAR CNRS 3427, US05 INSERM, France.
Benoit PinsonService Analyses Métaboliques-TBMCore University of Bordeaux, UAR CNRS 3427, US05 INSERM, France; Institute of Cellular Biochemistry and Genetics, UMR 5095 CNRS, University of Bordeaux, France.
Seyta Ley-NgardigalRare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Christelle DebeissatEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Biljana BursacInstitute of Cellular Biochemistry and Genetics, UMR 5095 CNRS, University of Bordeaux, France; Department of Biochemistry, Institute for Biological Research, University of Belgrade, Serbia.
Stéphane ClaverolUniversity of Bordeaux, Bordeaux Proteome, Bordeaux, France.
Radia KhelifiEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Laura RodriguezEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Philippe Brunet de la GrangeEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Rodrigue RossignolRare disease genetics and metabolism, Inserm U1211, University of Bordeux, France.
Milos R FilipovicLeibniz Institute for Analytical Sciences, ISAS e.V., Dortmund, Germany; Institute of Cellular Biochemistry and Genetics, UMR 5095 CNRS, University of Bordeaux, France; School of Molecular Biosciences, University of Glasgow, Scotland, UK. Electronic address: Milos.Filipovic@glasgow.ac.uk.
Zoran IvanovicEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France. Electronic address: Zoran.ivanovic@efs.sante.fr.
Marija Vlaski-LafargeEtablissement Français du Sang, Nouvelle Aquitaine, France; Rare disease genetics and metabolism, Inserm U1211, University of Bordeux, France. Electronic address: Marija.vlaski@efs.sante.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult stem cells, including mesenchymal stem cells (MSC), display marked metabolic flexibility, functioning across anaerobic to microaerophilic conditions. While their survival under energy-restrictive environments is known, the underlying metabolic mechanisms remain incompletely defined. Here, combining functional assays, omics, and multiparametric energetic profiling, we elucidate the adaptations that enable MSC, unlike differentiated cells, to endure prolonged anoxia or anoxia/aglycemia (ischemia-like) conditions. We show that MSC proliferation under anoxia and normal glycemia depends mainly on lactate fermentation, whereas survival under combined anoxia and aglycemia relies on a specific mitochondrial reprogramming. Notably, anaerobic mitochondrial activity including Krebs cycle turnover and sulfide oxidation can proceed through a canonical electron transport chain using an alternative electron acceptor. This anaerobiosis-stemness link positions stem cells as living molecular fossils, preserving features of primordial eukaryotic bioenergetics and illuminating the evolutionary depth of mitochondrial plasticity.

Indexed as

Mesenchymal Stem CellsAnaerobiosisAnimalsCell DifferentiationCell HypoxiaCell ProliferationCell SurvivalElectron TransportEnergy MetabolismHumansMetabolic ReprogrammingMitochondriaAglycemiaAnoxiaHydrogen sulfideMesenchymal stem cellsMitochondrial respiration

Identifiers

PMID42492361
PMCPMC13425896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.