Evidence map›Paper›PMID 42492293›Full record

ArticleJACC. Basic to translational science2026

IL-1-Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis.

David S Elias, Wonyoung Jo, Monica V Talor, Camille Jaime, Abdel Daoud, Ina Sulkaj, Martin Květoň, Nadan Wang, Ondřej Fabián, Vojtěch Melenovský and 1 more

Abstract read
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In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David S EliasDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Wonyoung JoDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Monica V TalorDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Camille JaimeDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Abdel DaoudW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Ina SulkajDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Martin KvětoňClinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Nadan WangDepartment of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Ondřej FabiánClinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Vojtěch MelenovskýClinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Daniela ČihákováDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: cihakova@jhmi.edu.

Funding

Cytek Aurora full spectrum flow cytometric analyzerS10OD026859 · OD · JOHNS HOPKINS UNIVERSITY · PI WANG, ZACK Z. · 2019 to 2019
$242k
NIH HHS S10 OD026859
6 · The paper itself

Abstract

We investigated how inflammatory fibroblasts (IFs) contribute to acute viral myocarditis, a dangerous inflammatory heart disease often caused by infections like coxsackievirus B3 (CVB3). Using CCL2-mCherry reporter mice, we tracked IF kinetics during CVB3 infection and discovered that their activity peaks on day 3 of myocarditis and is characterized by the production of Th1, Th2, and Th17 chemokines rather than typical profibrotic genes. We identified IL-1β as the most potent activator of this inflammatory state. We generated PDGFRα

Indexed as

IL-1inflammatory fibroblastsplasticityviral myocarditis

Identifiers

PMID42492293
PMCPMC13427423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.