Evidence map›Paper›PMID 42492292›Full record

ArticleJACC. Basic to translational science2026

Nanoparticle Biofunctionalization of Bioprosthetic Heart Valves to Modulate Mechanisms of Structural Valve Deterioration.

Angus J Grant, Alex H P Chan, Xueying S Xu, Kieran Lau, Timothy C Mitchell, Juichien Hung, Praveesuda L Michael, Miguel Santos, Aeryne Lee, Jacopo Giaretta and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Angus J GrantSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Center, University of Sydney, Sydney, New South Wales, Australia.
Alex H P ChanSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Xueying S XuSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Kieran LauSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Timothy C MitchellSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Juichien HungSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Praveesuda L MichaelSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Miguel SantosSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Aeryne LeeCharles Perkins Center, University of Sydney, Sydney, New South Wales, Australia; School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, New South Wales, Australia.
Jacopo GiarettaCharles Perkins Center, University of Sydney, Sydney, New South Wales, Australia; School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, New South Wales, Australia.
Tiffany GohSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Chi-Hui TsaoSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Anna WaterhouseSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Sina NaficyCharles Perkins Center, University of Sydney, Sydney, New South Wales, Australia; School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, New South Wales, Australia.
Jelena Rnjak-KovacinaSchool of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia; Tyree Foundation Institute of Health Engineering, Sydney, New South Wales, Australia.
Martin K C NgSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Steven G WiseSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Center, University of Sydney, Sydney, New South Wales, Australia.
Richard P TanSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Center, University of Sydney, Sydney, New South Wales, Australia. Electronic address: richard.tan@sydney.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioprosthetic heart valves made from glutaraldehyde-fixed animal pericardium are widely used for valve replacement but are prone to early degeneration arising from the interplay of thrombosis, inflammation, and calcification. Current chemical treatments passivate the tissue surface but do not address these biological processes. This study introduces a plasma polymerized nanoparticle (PPN) platform that enables rapid, uniform coating of bioprosthetic pericardium and provides binding sites for active drug functionalization. Using PPNs, we immobilized the anticoagulant apixaban, the selective NLRP3-inflammasome inhibitor MCC950, or the anticalcification compound phytic acid directly onto valve tissue. These functionalized coatings reduced thrombosis in vitro and limited fibrosis and calcification in a 28-day rat subcutaneous model, demonstrating the capacity of PPNs to conjugate different small molecules to target multiple mechanisms of valve deterioration. Importantly, PPN coatings did not alter leaflet mechanics or hemodynamic performance when applied to a commercial transcatheter valve. This versatile coating platform represents an important advance in bioprosthetic valve technology with significant implications for their performance.

Indexed as

drug immobilizationnanotechnologystructural valve deteriorationsurface functionalizationvalve coating

Identifiers

PMID42492292
PMCPMC13427470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.