Evidence map›Paper›PMID 42492253›Full record

ArticleUltrasonics sonochemistry2026

Multi-omics analysis reveals the mechanism of enhanced GABA production in Lactiplantibacillus plantarum JY7 under acoustic and thermal coupling.

Wenying Yuan, Hao Zhang, Lixin Cai, Xiefei Li, Daodong Pan, Zhen Wu, Jie Luo, Maiquan Li, Xiankang Fan, Hui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenying YuanSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Provincial Engineering Research Center of Ecological Food Innovation, Guizhou Medical University, Guiyang 561113, China; College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Hao ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Lixin CaiBeijing Zhongke Chuangyuan Technology Co., Ltd, China.
Xiefei LiSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Provincial Engineering Research Center of Ecological Food Innovation, Guizhou Medical University, Guiyang 561113, China. Electronic address: xiefeili.edu@gmail.com.
Daodong PanKey Laboratory of Animal Protein Food Processing Technology of Zhejiang Province, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China.
Zhen WuKey Laboratory of Animal Protein Food Processing Technology of Zhejiang Province, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China.
Jie LuoCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Maiquan LiCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Xiankang FanCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China; Key Laboratory of Animal Protein Food Processing Technology of Zhejiang Province, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China. Electronic address: fanxiankang2022@163.com.
Hui ZhouCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China. Electronic address: zhouhui@hunau.edu.cn.

Funding

NIEHS NIH HHS 27302C0138
6 · The paper itself

Abstract

The efficient microbial biosynthesis of γ-aminobutyric acid (GABA) remains challenging. This study investigated the molecular mechanism for high GABA production by Lactiplantibacillus plantarum JY7 under acoustic-thermal coupling. Lactiplantibacillus plantarum JY7 (isolated from fish intestines) exhibited the highest GABA yield (1.0014 mg/mL) among 425 lactic acid bacteria strains, demonstrating excellent acid tolerance and bile salt tolerance activity. Under the optimized conditions (0.5 % L-MSG, 45 μmol/L PLP, 150 W, 38℃), the acoustic-thermal coupled field treatment increased GABA yield by 2.1-fold (0.5104 ± 0.0238 mg/mL) relative to the control. Acoustic-thermal coupling enhances cell membrane permeability, thereby boosting substrate uptake and product efflux. This process directly upregulates key GABA biosynthetic genes (gadB/gadC), activates energy metabolism to augment precursor and ATP supply, initiates cellular repair and defence to maintain homeostasis, and redirects carbon flux to GABA synthesis. This provides a theoretical basis for the development of GABA-rich fermented foods.

Indexed as

Acousticsgamma-Aminobutyric AcidLactiplantibacillus plantarumTemperatureMultiomicsgamma-Aminobutyric AcidLactic acid bacteriaMetabolomicsTranscriptomicsUltrasonic processingγ-Aminobutyric acid

Identifiers

PMID42492253
PMCPMC13427605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.