Evidence map›Paper›PMID 42492092›Full record

Trial reportBreast (Edinburgh, Scotland)2026

[

Rosa Di Micco, Edoardo Botteri, Carla Canevari, Francesca Gallivanone, Lidjia Antunovic, Paola Scifo, Ilaria Neri, Fabrizia Gelardi, Patrizia Magnani, Claudio Losio and 21 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Breast (Edinburgh, Scotland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04826211 (Targeting the Future of Axillary Staging in Node Positive Breast Cancer Patients Receiving Primary Systemic Therapy. A Comparative Study Between Sentinel Node Biopsy vs PET/MRI.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04826211 nacompletednot on this map

Targeting the Future of Axillary Staging in Node Positive Breast Cancer Patients Receiving Primary Systemic Therapy. A Comparative Study Between Sentinel Node Biopsy vs PET/MRI.

TypeinterventionalSponsorIRCCS San RaffaeleRan2019 to 2024Enrolled109ConditionsBreast Cancer Female, Node-positive Breast Cancer, Sentinel Lymph NodeArmsPET/MRI
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Rosa Di MiccoBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Edoardo BotteriBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy; Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Carla CanevariNuclear Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Francesca GallivanoneInstitute of Molecular Bioimaging and Physiology, National Research Council, Milan, Italy.
Lidjia AntunovicNuclear Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Paola ScifoNuclear Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Ilaria NeriNuclear Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Fabrizia GelardiUniversità Vita-Salute San Raffaele, Milan, Italy.
Patrizia MagnaniNuclear Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Claudio LosioBreast Radiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Elena VenturiniBreast Radiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Giovanna Della VecchiaBreast Radiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Goffredo FerrareseBreast Radiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Nicole RotmenszBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Veronica ZuberBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Sara BaleriBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Giovanni CisterninoBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Francesca CalabrettoBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Silvia P CoronaBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Mario RampaBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Dema Wahid S HammamiBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Vitalba ScadutoBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Manuela M MorganteBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Giulia VialeOncology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Marta PirasOncology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Luca LicataOncology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Isabella SassiPathology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Giampaolo BianchiniUniversità Vita-Salute San Raffaele, Milan, Italy; Oncology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Pietro PanizzaBreast Radiology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Arturo ChitiNuclear Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy.
Oreste D GentiliniBreast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy. Electronic address: gentilini.oreste@hsr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManagement of axillary nodes in breast cancer (BC) remains controversial. Increasingly, node-positive patients receive primary systemic therapy (PST), achieving axillary downstaging in up to 70% of cases. However, current imaging methods, despite being pivotal in the choice for PST, show limited accuracy in assessing treatment response. This study evaluated the diagnostic performance of hybrid [

methodsThis prospective, single-arm, monocentric interventional trial (SNBvsPET/MRI1, ClinicalTrials.gov NCT04826211) was conducted at San Raffaele Scientific Institute, Milan. Patients with node-positive BC eligible for PST were enrolled between September 2019 and December 2024. In addition to routine imaging, including axillary ultrasound (A-US), [

findingsOf 109 screened patients, 68 were included in the final analysis Mean(SD) age was 52.3(11.0) years. Residual axillary disease was pathologically confirmed in 30(44.2%) patients. [ INTERPRETATIONS: [

Indexed as

Breast NeoplasmsLymphatic MetastasisLymph NodesMagnetic Resonance ImagingPositron-Emission TomographyAdultAgedAxillaFemaleFluorodeoxyglucose F18HumansMiddle AgedMultimodal ImagingNeoplasm StagingProspective StudiesRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsAxillary stagingNode-positive breast cancerPET/MRIPrimary systemic therapy

Identifiers

PMID42492092
PMCPMC13427588

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.