ArticleJournal of veterinary internal medicine2026
Effects of cow placenta extract on cognitive function in aged dogs: a randomized controlled trial.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundCow placenta extract (CPE) has demonstrated beneficial effects in antiaging; however, its effect on age-related cognitive decline remains unclear. HYPOTHESIS/
objectivesTo evaluate the potential therapeutic benefits of CPE in improving cognitive function in aged dogs. ANIMALS: The aged dogs (≥7 years) with a Canine Social and Learning Behavior Survey (CSLB) score of ≥ 30 owned by clients.
methodsA 6-month randomized controlled trial. Eighty-eight dogs received CPE (n = 45) or placebo (n = 43). Canine Social and Learning Behavior Survey questionnaires were administered, and serum oxidative stress markers were assessed.
resultsBy month 6, the mean ± SD of CSLB was 35.1 ± 4.9 in the CPE group vs 41.1 ± 5.3 (P < .05; Cohen's d = -1.17; 95% CI for d: -1.63 to -0.72) in the placebo group. The successful therapeutic response was 77.8% (95% CI, 63.2-88.0) in the CPE group vs 9.3% (95% CI, 3.1-22.3; P < .001) in the placebo group. The correlation between the change (Δ%) in CSLB and change in malondialdehyde (MDA) was positive (r = 0.77, P < .001), and correlations between the Δ% in CSLB and change in glutathione peroxidase (GSH-Px) and glutathione (GSH) were negative (r = -0.893, P < .001 and r = -0.878, P < .001, respectively). CONCLUSIONS AND CLINICAL IMPORTANCE: A six-month CPE administration improved cognitive function and oxidative stress in aged dogs, suggesting its potential for long-term management of cognitive impairment.
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