ReviewJournal of medical ultrasound
Umbilical Artery Thrombosis in Pregnancy: A Systematic Review and Case-based Insight into Doppler Diagnosis, Pathophysiology, and Perinatal Outcomes.
Review in Journal of medical ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Umbilical artery thrombosis (UAT) is a rare but important cause of fetal compromise. Once considered a postnatal diagnosis, improved Doppler ultrasonography now permits antenatal identification. A unified synthesis of diagnostic features, mechanisms, and outcomes is needed to support clinical decision-making. The objective of the study is to summarize prenatal diagnostic characteristics, underlying pathophysiology, and perinatal outcomes of UAT, complemented by an illustrative clinical case. Methods: A PRISMA-guided search of PubMed, Scopus, Embase, and Web of Science through September 2025 identified reports describing prenatal or perinatal UAT confirmed by Doppler ultrasonography or histopathology. Fifty-five studies met the inclusion criteria. Extracted data included gestational age at diagnosis, Doppler findings, associated factors, mechanistic context, and outcomes. Study quality was appraised using NOS, JBI, AMSTAR-2, and ROBIS. Results: Diagnosis occurred between 10 and 39 weeks, most often in the late second or third trimester. The hallmark prenatal finding was unilateral absent end-diastolic velocity with preserved flow in the contralateral artery. Additional indicators included color asymmetry, flow-trajectory disturbance, and wave-reflection changes. Mechanistic patterns reflected Virchow's triad, encompassing stasis, hypercoagulability, endothelial injury, and structural or placental contributors. Perinatal outcomes were generally favorable when unilateral thrombosis was detected and monitored, whereas unrecognized or bilateral occlusion was associated with fetal growth restriction or intrauterine demise. An illustrative case confirmed the value of advanced Doppler trajectory mapping in enabling early diagnosis and timely delivery. Conclusion: Targeted Doppler interrogation allows reliable prenatal detection of UAT. Incorporating mechanistic Doppler markers and standardized reporting may enhance diagnostic accuracy and support informed delivery planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.