Evidence map›Paper›PMID 42491956›Full record

ArticleiScience2026

Age and sex-dependent tumor microbiome programs shape pancreatic cancer prognosis.

Jun Yang, Yajing Guo, Shang Cai, Longyun Ye, Pengcheng Zhou, Yong Li, Shuaiwu Luo, Zhenduo Shao, Zhihao Huang, Wenjun Liao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jun YangDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yajing GuoWestlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Shang CaiWestlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Longyun YeDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Pengcheng ZhouDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yong LiDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Shuaiwu LuoDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhenduo ShaoDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhihao HuangDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Wenjun LiaoDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Hui ChenThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yali LiThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Linquan WuDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Wei ChenDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Enliang LiDepartment of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer prognosis is shaped by host factors and the tumor microenvironment. Here, we identify a survival advantage in young female (≤55 years) pancreatic cancer patients-absent in older patients and males. Integrated analysis of SEER and TCGA datasets reveals that host immune and inflammatory pathways associated with bacterial response are enriched in young males, old males, and old females, but notably absent in young females. Direct microbial profiling of 30 pancreatic tumors shows that young female tumors harbor a distinct microbiome with lower

Indexed as

cancer microenvironmentpancreatic cancerprognostic biomarkersex differencestumor microbiome

Identifiers

PMID42491956
PMCPMC13378360

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.