Evidence map›Paper›PMID 42491877›Full record

ArticleiScience2026

Helminth proteins recapitulate key structural motifs of MIF to facilitate immunomodulation of host receptors.

Jacob A Orkwis, Ramu Manjula, Elias J Lolis

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob A OrkwisDepartment of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA.
Ramu ManjulaDepartment of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA.
Elias J LolisDepartment of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Funding

TRAINING PROGRAM IN INVESTIGATIVE RHEUMATOLOGYT32AR007107 · NIAMS · YALE UNIVERSITY · PI RICHARD J BUCALA · 1986 to 2026
$7.5M
NIAMS NIH HHS T32 AR007107
6 · The paper itself

Abstract

Parasite-derived homologs of the cytokine macrophage migration inhibitory factor (MIF) function as virulent factors during parasitic infection. Recent evidence suggests MIF-like products from multicellular

Indexed as

Biological sciences

Identifiers

PMID42491877
PMCPMC13378023

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.