Evidence map›Paper›PMID 42491814›Full record

ArticlePain reports2026

Dopamine transporter gene (

Keiko Yamada, Daisuke Nishizawa, Hideko Arita, Kazuo Hanaoka, Choku Yajima, Jitsu Kato, Setsuro Ogawa, Ayako Hiranuma, Junko Hasegawa, Yuko Ebata and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Keiko YamadaPain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4378-3290
Daisuke NishizawaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8286-4651
Hideko AritaDepartment of Anesthesiology, Pain Relief Center, JR Tokyo General Hospital, Tokyo, Japan.
Kazuo HanaokaDepartment of Anesthesiology, Pain Relief Center, JR Tokyo General Hospital, Tokyo, Japan.
Choku YajimaDepartment of Anesthesiology, Pain Relief Center, JR Tokyo General Hospital, Tokyo, Japan.
Jitsu KatoDepartment of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan.
Setsuro OgawaUniversity Research Center, Nihon University, Tokyo, Japan.
Ayako HiranumaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Junko HasegawaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yuko EbataAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kyoko NakayamaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Masako IsekiPain Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Kazutaka IkedaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic pain exhibits significant interindividual variability, partly because of genetic factors. The dopaminergic system is implicated in pain modulation. Objectives: This study investigated the association between single-nucleotide polymorphisms (SNPs) in dopamine pathway genes and chronic pain susceptibility in a Japanese population. Methods: A case-control study compared 191 patients with chronic pain with 282 healthy controls in Japan. Genotype data from previous whole-genome studies were analyzed for SNPs within or flanking 8 candidate genes (tyrosine hydroxylase, solute carrier family 6 member 3 [ Results: After quality control, 184 SNPs were analyzed. A significant association was identified between the rs2963257 SNP flanking the Conclusions: The

Indexed as

Chronic painDopamine transporterGenetic associationSingle-nucleotide polymorphismSLC6A3

Identifiers

PMID42491814
PMCPMC13379058

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.