Evidence map›Paper›PMID 42491803›Full record

ArticleJAC-antimicrobial resistance2026

The microbiological profile of diabetic foot infections: historical trends and relationship with amputation.

Diego Agustín Abelleyra Lastoria, Filzah Khan, Robert Leatherby, Amber Arnold, Peter Edward Holt, Paul Moxey, Anna Louise Pouncey, Iain Nicholas Roy, James John Rowland Budge

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Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diego Agustín Abelleyra LastoriaInstitute of Medical, Biomedical and Allied Health Education, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.ORCID https://orcid.org/0000-0002-1901-8214
Filzah KhanInstitute of Medical, Biomedical and Allied Health Education, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Robert LeatherbyInstitute of Medical, Biomedical and Allied Health Education, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Amber ArnoldSt George's Vascular Institute, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
Peter Edward HoltSt George's Vascular Institute, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
Paul MoxeySt George's Vascular Institute, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
Anna Louise PounceyInstitute of Medical, Biomedical and Allied Health Education, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Iain Nicholas RoySt George's Vascular Institute, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.ORCID https://orcid.org/0000-0001-9701-8319
James John Rowland BudgeInstitute of Medical, Biomedical and Allied Health Education, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Understanding the microbial composition of diabetic foot infections (DFIs) is required to deliver appropriate antimicrobial therapy and to establish prognosis. Objectives: We aimed to evaluate historical trends in the microbiological profile of DFIs and to explore the relationship between antimicrobial resistance and the risk of amputation. Patients and methods: This was a retrospective study of patients with DFI treated in a tertiary vascular surgery centre between 2014 and 2024. The prevalence of different DFI organisms and the percentage of patients with organisms exhibiting resistance to DFI first-line antibiotics were calculated. The relationship between resistance to first-line options and amputation was established. Results: There were 1164 samples collected from 274 patients (215 males, 78.5%). Prevalence of Conclusions: Presence of organisms resistant to PA antibiotics is associated with a higher risk of amputation in a South-West London DFI population. This study highlights a rise in resistance to first-line antibiotics used in PA patients, underscoring the need for continuous surveillance of DFI microbiology resistance patterns to guide empirical therapy.

Identifiers

PMID42491803
PMCPMC13378766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.