Evidence map›Paper›PMID 42491772›Full record

ArticleiScience2026

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function.

Lin Tze Tung, Roselyn R Jiang, Bianca Pozzebon, Mathieu Mancini, Lucie Droin, Mitra Yousefi, Joo Eun June Kim, Marwah Mousa, Yue Liang, Connie M Krawczyk and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lin Tze TungDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Roselyn R JiangDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Bianca PozzebonDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Mathieu ManciniMcGill University Research Centre on Complex Traits, McGill University, Montreal, QC H3G 0B1, Canada.
Lucie DroinDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Mitra YousefiMcGill University Research Centre on Complex Traits, McGill University, Montreal, QC H3G 0B1, Canada.
Joo Eun June KimDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Marwah MousaDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Yue LiangDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Ines ColmegnaDivision of Rheumatology, Department of Medicine, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
Danielle MaloMcGill University Research Centre on Complex Traits, McGill University, Montreal, QC H3G 0B1, Canada.
David LanglaisMcGill University Research Centre on Complex Traits, McGill University, Montreal, QC H3G 0B1, Canada.
Silvia M VidalMcGill University Research Centre on Complex Traits, McGill University, Montreal, QC H3G 0B1, Canada.
Anastasia NijnikDepartment of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis affects ∼1% of adult population, results in joint inflammation and systemic comorbidities, and is driven by pathogenic hyperactivation of both innate and adaptive immune systems. We demonstrate that emergency myelopoiesis is induced in rheumatoid arthritis, enhancing innate immune cell production and generating functionally altered innate immune cells. Importantly, these mechanisms impact dendritic cells-antigen-presenting cells that bridge innate and adaptive immune responses. Such effects are intrinsic to hematopoietic stem and progenitor cells (HSPCs) and persist

Indexed as

dendritic cellsemergency myelopoiesishematopoiesisinflammationmouse modelsRheumatoid arthritistrained immunity

Identifiers

PMID42491772
PMCPMC13378370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.