Evidence map›Paper›PMID 42491763›Full record

ArticleiScience2026

High TMEM161A expression drives malignant phenotypes and predicts poor prognosis in colorectal cancer.

Kengo Haruna, Norikatsu Miyoshi, Shiki Fujino, Rie Mizumoto, Yuki Toyoda, Rie Hayashi, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kengo HarunaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Norikatsu MiyoshiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Shiki FujinoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Rie MizumotoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Yuki ToyodaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Rie HayashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Mitsunobu TakedaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Yuki SekidoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Tsuyoshi HataDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Atsushi HamabeDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Takayuki OginoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Mamoru UemuraDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Hirofumi YamamotoDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transmembrane protein 161 A (TMEM161A), also known as adaptive response to oxidative stress-29, has been implicated in cellular stress responses, but its role in colorectal cancer (CRC) remains unclear. Here, we investigated the clinical relevance and functional significance of TMEM161A in CRC, using integrated clinical, experimental, and transcriptomic analyses. Immunohistochemical analysis of 133 surgically resected CRC specimens showed that high TMEM161A expression was associated with worse survival outcomes in our institutional cohort. Functional assays using siRNA-mediated

Indexed as

cancer stemnesscell cyclecolorectal cancerprognostic biomarkerTMEM161A

Identifiers

PMID42491763
PMCPMC13378339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.