Evidence map›Paper›PMID 42491728›Full record

ArticlePeerJ2026

Clinical strains isolated from early-stage colorectal cancer patients promote tumorigenesis.

Daisuke Suzuki, Jiayue Yang, Nozomu Obana, Shinichi Yachida, Satoshi Shiba, Sayaka Mizutani, Hiroyuki Takamaru, Yutaka Saito, Shinji Fukuda, Takuji Yamada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daisuke SuzukiSchool of Life Science and Technology, Institute of Science Tokyo, Tokyo, Japan.
Jiayue YangInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
Nozomu ObanaTransborder Medical Research Center, University of Tsukuba, Ibaraki, Japan.
Shinichi YachidaDepartment of Cancer Genome Informatics, The University of Osaka, Osaka, Japan.
Satoshi ShibaDivision of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Sayaka MizutaniSchool of Life Science and Technology, Institute of Science Tokyo, Tokyo, Japan.
Hiroyuki TakamaruEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Yutaka SaitoEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Shinji FukudaInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
Takuji YamadaSchool of Life Science and Technology, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) is prevalent worldwide and is associated with gut commensals. Recent studies have highlighted the effects of gut microbes on CRC development driven by their strain diversity. Nevertheless, the impact of the gut microbial community on tumorigenesis in early-stage (ES) CRC remains unexplored. Methods: To assess the potential gut microbial community, which is critical to tumorigenesis in early-stage CRC, we collected publicly available shotgun metagenomes from CRC patient faecal samples from a Japanese population. Correlation analysis of the microbial profiles derived from the metagenomes revealed an ES CRC-associated community. To elucidate the strain diversity of the targeted community, we isolated strains from ES CRC patient faecal samples and employed comparative genomics. To evaluate the strain-specific effects of the community on tumorigenesis, we introduced an isolated strain cocktail into a CRC mouse model. Results: Among the most significant ES CRC-associated species, we identified

Indexed as

CarcinogenesisColorectal NeoplasmsGastrointestinal MicrobiomeAnimalsFecesFemaleHumansMaleMetagenomeMiceComparative genomicsEarly-stage colorectal cancerGut microbiotaStrain diversity

Identifiers

PMID42491728
PMCPMC13378470

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.