Evidence map›Paper›PMID 42491727›Full record

ArticleiScience2026

Butyrate causes loss of specific acetylation by the histone acetyltransferase p300.

Muwei Jiang, Anthi Psoma, Jinxiao Lyu, Maria Gabriella Chiariello, Rutger Modderman, Frans Bianchi, Danny Incarnato, Siewert-Jan Marrink, Iris H Jonkers, Geert van den Bogaart

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muwei JiangDepartment of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Anthi PsomaDepartment of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Jinxiao LyuDepartment of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Maria Gabriella ChiarielloDepartment of Molecular Dynamics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Rutger ModdermanDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Frans BianchiDepartment of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Danny IncarnatoDepartment of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Siewert-Jan MarrinkDepartment of Molecular Dynamics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.
Iris H JonkersDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Geert van den BogaartDepartment of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG, Nijenborgh 7, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Butyrate, a short-chain fatty acid produced by microbial fermentation of dietary fiber, exerts beneficial metabolic and immunomodulatory functions through butyrylation of the histone acetyltransferase p300. This is thought to result in histone hyperacetylation at transcription starting sites and enhancers that regulate specific genes. However, we show that butyrate-induced hyperacetylation is not specific but occurs at histones throughout the entire genome. Mechanistically, our data show that butyrylation of p300 prevents its recruitment to acetylated histones through its bromodomain, and thereby p300 cannot maintain the acetylation of specific histones through positive feedback. Thus, the epigenetic regulation of specific genes by butyrate is limited, but butyrate instead increases histone acetylation globally along the entire chromatin structure.

Indexed as

acetylationbutyratehistonesp300SCFA

Identifiers

PMID42491727
PMCPMC13378256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.