Evidence map›Paper›PMID 42491700›Full record

ArticleiScience2026

WNK-SPAK-NKCC1/KCC2 pathway disrupts chloride homeostasis and drives hyperactivation of PVN-CRH neurons in essential hypertension.

Xinqi Guo, Hongyu Ma, Qiyue Zhao, Ying Zhang, Peiyun Yang, Qian Zhao, Lu Jia, Liping Zhang, Yue Guan, Yuanyuan Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinqi GuoDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Hongyu MaDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Qiyue ZhaoDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Ying ZhangDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Peiyun YangDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Qian ZhaoDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Lu JiaDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Liping ZhangDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Yue GuanDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Yuanyuan ZhangSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, China.
Suibing MiaoInstitute of Reproductive Medicine of Shijiazhuang, The Fourth Hospital of Shijiazhuang, Gynecology and Obstetrics Hospital Affiliated to Hebei Medical University, Shijiazhuang 050011, China.
Huijie MaDepartment of Physiology, Hebei Medical University, Shijiazhuang 050017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperactivity of hypothalamic corticotropin-releasing hormone (CRH) neurons contributes to elevated sympathetic outflow in hypertension, but the underlying mechanisms remain unclear. Here, we demonstrate that activation of the WNK-SPAK-NKCC1/KCC2 pathway disrupts chloride homeostasis in paraventricular nucleus (PVN) CRH neurons, diminishing GABAergic inhibition and driving neuronal hyperactivity in spontaneously hypertensive rats (SHRs). Chemogenetic inhibition of PVN-CRH neurons reduced blood pressure and renal sympathetic nerve activity in SHRs. We found depolarizing shifts in GABA reversal potential (

Indexed as

chloride homeostasiscorticotropin-releasing hormone neuronhypertensionhypothalamic paraventricular nucleusWNK-SPAK-NKCC1/KCC2 pathway

Identifiers

PMID42491700
PMCPMC13378147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.