Evidence map›Paper›PMID 42491696›Full record

ArticleiScience2026

Microglia and its P2RY12 receptors regulate seizure severity.

Leigh Ellen Fremuth, Synphane Gibbs-Shelton, Madison Doceti, Aida Oryza Lopez-Ortiz, Abigayle Duffy, William A Mills, Ronald P Gaykema, Kiran Singh, Audrey Nguyen, Sophia Cheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Leigh Ellen FremuthBrain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA.
Synphane Gibbs-SheltonBrain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA.
Madison DocetiDepartment of Microbiology, Immunology and Cancer, University of Virginia, Charlottesville, VA, USA.
Aida Oryza Lopez-OrtizBrain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA.
Abigayle DuffyBrain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA.
William A MillsBrain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA.
Ronald P GaykemaDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Kiran SinghDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Audrey NguyenDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Sophia ChengDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Edward Perez-ReyesDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Ukpong B EyoBrain Immunology and Glia Center, University of Virginia, Charlottesville, VA, USA.

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Targeting Microglia in Febrile Status EpilepticusR01NS119243 · NINDS · UNIVERSITY OF VIRGINIA · PI EYO, UKPONG BASSEY · 2021 to 2025
$2.4M
Training in the Pharmacological SciencesT32GM148379 · NIGMS · UNIVERSITY OF VIRGINIA · PI Michelle L Bland, Thurl E. Harris · 2023 to 2026
$1.3M
Validation of a novel mouse model of temporal lobe epilepsyR61NS112549 · NINDS · UNIVERSITY OF VIRGINIA · PI PEREZ-REYES, EDWARD · 2019 to 2020
$727k
Validation of a Novel Mouse Model of Temporal Lobe EpilepsyR33NS112549 · NINDS · UNIVERSITY OF VIRGINIA · PI PEREZ-REYES, EDWARD · 2022 to 2022
$407k
NHLBI NIH HHS T32 HL007284NIGMS NIH HHS T32 GM148379NINDS NIH HHS R01 NS119243NINDS NIH HHS R33 NS112549NINDS NIH HHS R61 NS112549
6 · The paper itself

Abstract

Microglia are possible regulators of seizures but previous employed approaches are insufficiently selective of microglial-specific manipulations. To more definitely determine microglial roles in seizure severity, we used the microglial-deficient

Indexed as

border-associated macrophagesexcitabilityFIRE micemicroglianeuronal activityP2RY12seizures

Identifiers

PMID42491696
PMCPMC13378365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.