Evidence map›Paper›PMID 42491638›Full record

ArticleiScience2026

A systematic review on deep learning techniques for diabetic retinopathy classification in retinal fundus images.

José Araque-Gallardo, Eugenia Arrieta-Rodríguez, Lenis Rueda-Gómez, Oscar Teherán-Forero, Emiro De-La-Hoz-Franco, Margarita Gamarra, Javier Sierra-Carrillo, José Escorcia-Gutierrez

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

José Araque-GallardoDepartment of Electronic Engineering, Universidad de Sucre, Sincelejo 700001, Colombia.
Eugenia Arrieta-RodríguezDepartment of Computational Science and Electronics, Universidad de la Costa, CUC, Barranquilla 080002, Colombia.
Lenis Rueda-GómezUniversidad del Sinú-Elias Bechara Zainúm, Seccional Cartagena, Cartagena 130001, Colombia.
Oscar Teherán-ForeroUniversidad del Sinú-Elias Bechara Zainúm, Seccional Cartagena, Cartagena 130001, Colombia.
Emiro De-La-Hoz-FrancoDepartment of Computational Science and Electronics, Universidad de la Costa, CUC, Barranquilla 080002, Colombia.
Margarita GamarraDepartment of System Engineering, Universidad del Norte, Puerto Colombia 081007, Colombia.
Javier Sierra-CarrilloDepartment of Electronic Engineering, Universidad de Sucre, Sincelejo 700001, Colombia.
José Escorcia-GutierrezDepartment of Computational Science and Electronics, Universidad de la Costa, CUC, Barranquilla 080002, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide, particularly in low- and middle-income countries. Although expert analysis of color fundus images (CFIs) enables reliable classification, this process is time-consuming. In recent years, deep learning (DL) techniques have demonstrated remarkable performance in analyzing CFI for the detection (binary classification) and multi-class classification of DR. To synthesize recent advances in this field, this study presents a systematic review, analyzing 146 peer-reviewed studies published between 2019 and 2025. This review examines lesion detection and segmentation, as well as DR detection and classification in CFI using two approaches: direct full-image and lesion-based classification. In addition, a brief scientometric analysis was performed to identify publication trends, leading journals, and countries contributing to this domain. The insights provided by this review aim to support researchers in selecting effective strategies and advancing the development of DL-based systems for the detection and classification of DR.

Indexed as

Health sciencesMedical specialtyMedicineOphthalmology

Identifiers

PMID42491638
PMCPMC13378343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.